Hesham A. Khalifa, Asmaa M. Elattar, Naglaa Z.H. Eleiwa


Alhagi maruroum, a species of family leguminosae, has high contents of flavonoids, triterpenes, sterols and glycosides. It is a woody perennial herb that was used in the folk medicine for gastric disturbance, rheumatic pains, liver disease and urinary tract infection. This study was designed to spot the light on some pharmacological activities of Alhagi maurorum. The fresh aerial parts of the plant were washed, dried at room temperature, crushed into fine powder, extracted with 80% methanol for three days with frequent agitation, filtrated and dried by rotatory evaporator under reduced pressure at 45°C. The concentrated filtrate then was lyophilized in lyophilizer. The extract was tested for some pharmacological activities (analgesic, anti-inflammatory and antiulcerogenic) in rats and mice. The current results proved that administration of Alhagi maurorum aqueous methanolic extract in mice at dose of 200 and 400 mg/kg BW exhibited analgesic effect that was noticed from a significant elevation in the reaction time of mice in a dose dependent manner when compared to the control mice by using hot plate method. Moreover, Alhagi maurorum aqueous methanolic extract demonstrated anti-inflammatory effect by using hind paw edema method in rats as confirmed by a significant dose dependent reduction in the thickness of the hind paw edema compared with the control group. Additionally, administration of Alhagi extract elicited a significant improvement in gastric damage induced by indomethacin in rats where mean ulcer score in alhagi 200 and alhagi 400 groups was 1.25±0.045 and 0.25±0.004, respectively compared with 1.75±0.054 of indomethacin group. It could be deduced from those results that Alhagi maurorum aqueous methanolic extract owns analgesic, anti-inflammatory, and antiulcerogenic activities.

Key words: Alhagi maurorum; aqueous methanolic extract; analgesic; anti-inflammatory; anti-ulcerogenic

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