ASSESSMENT OF CIRCULATING TOTAL AND FREE IODOTHYRONINES’ PATTERNS IN ADULT OVINE AND CAPRINE SPECIMENS: INFLUENCES OF ENDEMIC GOITRE AREA

Esterina Fazio, Pietro Medica, Cristina Cravana, Adriana Ferlazzo

Abstract


North-eastern Sicily is an area with iodine deficiency disorders occurring in both humans and animals. The aim of this study was to test the influences of an endemic goitre area on iodothyronine ranges and their pattern in adult ovine and caprine specimens stabled in different locations of Sicily, taking into account the different sexes. A total of 48 Comisana sheep and 51 Maltese goats was studied. The sheep included 10 females and 6 males stabled in a non-endemic goitre area (farm A: control group), and 16 females and 16 males stabled in an endemic goitre area (farm B: observational group). The goats included 6 females and 13 males stabled in a non-endemic goitre area (farm A: control group), and 16 females and 16 males stabled in an endemic goitre area (Farm B: observational group). The results showed lower T3 and higher fT4 (P<0.0001) levels in female and male sheep, and higher T4 levels in males (P<0.0001) stabled in farm B than in farm A. In comparison to farm A, goats stabled in farm B showed higher fT3 (P<0.0001) levels; males stabled in farm B showed lower T4 levels (P<0.0001), and females showed higher fT4 levels (P<0.0001). Significant effects of sex and of endemic goitre area on the total and free iodothyronines of sheep and goats were observed. The obtained data showed that an endemic goitre area for humans is not necessarily the same for ovine and caprine species, which seem to be able to adopt an adaptive strategy without presenting any clinical signs of thyroid disorders.

Key words: thyroid hormones; sheep; goat; endemic goitre area

 

DOLOČANJE VEZANIH IN PROSTIH ŠČITNIČNIH HORMONOV V KRVI PRI ODRASLIH OVCAH IN KOZAH: VPLIV ENDEMIČNIH OBMOČIJ Z GOLŠAVOSTJO

Severovzhodna Sicilija je območje, kjer se redno pojavljajo motnje, povezane s pomanjkanjem joda pri ljudeh in živalih. Cilj raziskave je bil raziskati pojavnost endemične golšavosti pri odraslih ovcah in kozah z merjenjem ravni jodotironinov na različnih lokacijah na Siciliji. Upoštevane so bile tudi razlike med spoloma. Skupno je bilo v raziskavo vključenih 48 ovc pasme comisana in 51 malteških koz. Pri ovcah je bilo vključenih 10 samic in 6 samcev z območij brez golšavosti (kmetija A: kontrolna skupina) ter po 16 samic in samcev iz endemičnih območij z golšavostjo (kmetija B: opazovana skupina). Pri kozah je bilo vključenih 6 samic in 13 samcev iz območij brez golšavosti (kmetija A: kontrolna skupina) in po 16 samic in samcev iz endemičnih območij z golšavostjo (kmetija B: opazovana skupina). Rezultati so pokazali nižje T3 in višje T4 vrednosti (p <0,0001) pri samcih in samicah ovac in višje ravni T4 pri samcih (p >< 0,0001), ki so bili nastanjeni na kmetiji B v primerjavi s kmetijo A. V primerjavi s kmetijo A so pri kozah, ki so bile nastanjene na kmetiji B, ugotovili višje ravni prostega T3 (p < 0,0001), pri samcih na kmetiji B nižje ravni T4 (p < 0,0001), pri samicah pa višjo raven prostega T4 (p < 0,0001). Ugotovljene so bile statistično značilne razlike med skupinami tako glede na spol kot glede na endemičnost področja na ravni vezanih in prostih jodotironinov pri ovcah in kozah. Pridobljeni podatki so pokazali, da območja z endemično golšavostjo pri ljudeh nimajo nujno enakega učinka pri ovcah in kozah, za katere se zdi, da so sposobne ustvariti prilagoditveno strategijo, zaradi katere se ne pokažejo klinični znaki bolezni ščitnice.

Ključne besede: ščitnični hormoni; ovce; koze; endemična območja z golšavostjo


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