EFFECT OF Boswellia serrata SUPPLEMENTATION IN ADDITION TO INSULIN ON GLYCEMIC CONTROL IN A DIABETIC DOG

Giulia Andreani, Enea Ferlizza, Elisabetta Macrì, Daniela Beghelli, Gloria Isani

Abstract


Diabetes mellitus (DM) is a common disorder in middle-aged to older dogs. Treatment options, similar to those for humans, include insulin injection, dietary changes and exercise. Since some diabetic dogs may develop humoral immune responses to exogenous insulin resulting in treatment failure, the use of alternative medicine could represent an interesting new therapeutic strategy for DM in addition to the traditional insulin therapy. The main objective of this report was to evaluate a new therapeutic strategy for DM, based on the association of insulin injections with an orally administered extract of Boswellia serrata to improve glycemic control in a diabetic dog. A nine year old female neutered mixed breed dog diagnosed with DM was treated with increasing doses of a porcine insulin zinc suspension starting from 0.2 U/kg up to 0.6 U/kg q 12 hours. Twenty weeks after the start of insulin therapy the duration of effect and glucose nadir were ideal and clinical symptoms had disappeared but hyperglycemia, although less severe, persisted. Supplementation with a dry extract from the gum- resin of Boswellia serrata was initiated, at a dosage of 15 mg/kg q 12 hours, to improve insulin sensitivity or possible remaining endogenous insulin secretion. B. serrata supplementation led to good glycemic control. No side-effect or adverse reaction were observed during the study.
The present case report provides the first evidence in veterinary medicine of a positive effect of dietary supplementation with boswellic acids associated with traditional insulin therapy on glycemic control in a diabetic dog. A major pitfall of the study is the lack of a control. More extensive clinical trials are required to provide definitive evidence of B. serrata efficacy.

Key words: diabetes mellitus; dog; boswellic acids; glycemic control

 

VPLIV DODAJANJA BOSVELIJE (Boswellia serrata) OB ZDRAVLJENJU Z INZULINOM NA UREJANJE RAVNI GLUKOZE V KRVI PRI PSU S SLADKORNO BOLEZNIJO

Sladkorna bolezen oz. diabetes mellitus (DM) je pogosta motnja pri psih v srednjih letih in starejših psih. Možnosti zdravljenja, ki so podobne kot pri ljudeh, vključujejo dodajanje inzulina, spremembe v prehrani in telesno aktivnost. Ker lahko nekateri psi s sladkorno boleznijo razvijejo imunski odziv na dodajanje inzulina, kar lahko vodi do neuspešnega zdravljenja, lahko uporaba alternativne medicine predstavlja zanimivo novo metodo zdravljenja DM poleg tradicionalnega zdravljenja z inzulinom. Glavni cilj raziskave je bil ovrednotiti novo metodo zdravljenja DM, ki temelji na hkratnem dodajanju inzulina in peroralnem dodajanju izvlečka bosvelije (Boswellia serrata) za izboljšanje urejanja ravni glukoze v krvi pri psu s sladkorno boleznijo. Devet let stara sterilizirana samica mešane pasme, ki je bila diagnosticirana s sladkorno boleznijo, je bila zdravljena z naraščajočimi odmerki suspenzije prašičjega inzulina in cinka (od 0,2 E/kg do 0,6 U/kg), ki jih je dobivala vsakih 12 ur. Dvajset tednov po začetku zdravljenja z inzulinom so bili učinki in najnižja vrednost izmerjene glukoze v normalnih mejah vrednosti, klinični simptomi so izginili, le hiperglikemija je bila še vedno prisotna, vendar pa je bila manj resna. Dodatek suhega izvlečka iz gumijeve smole bosvelije Boswellia serrata v odmerku 15 mg/kg vsakih 12 ur je povečal občutljivost na inzulin oz. morebitne preostanke endogenega izločanja inzulina. Dodatek B. serrata je pozitivno vplival na nadzorovanje sladkorne bolezni. Med zdravljenjem niso bili opaženi stranski ali nezaželeni učinki. Poročilo o opisanem primeru vsebuje prve dokaze o pozitivnem učinku prehranskega dopolnila z bosveličnimi kislinami v veterinarski medicini, povezanimi z običajnim zdravljenjem z inzulinom, pri nadzoru glukoze v krvi pri psu s sladkorno boleznijo. Najbolj neugoden del te študije je odsotnost kontrole. Za zagotovitev dokončnega dokaza o učinkovitosti B. serrata so potrebni obsežnejši klinični poskusi.

Ključne besede: diabetes mellitus; pes; bosvelična kislina; nadzor sladkorne bolezn


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References


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DOI: http://dx.doi.org/10.26873/SVR-248-2017

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