THE GROWING POTENTIAL OF EXTRACELLULAR VESICLE RESEARCH IN VETERINARY MEDICINE
DOI:
https://doi.org/10.26873/SVR-2195-2025Keywords:
extracellular vesicles, regenerative veterinary medicine, biomarker, therapy, cargoAbstract
Extracellular vesicles (EVs) are small, information-rich subcellular structures that have attracted considerable attention in the scientific community. Their ubiquitous presence in the body and their natural role as cellular messengers make them valuable indicators of the physiological and pathological state of cells and tissues. Currently, the number of specific studies on the presence, properties and role of EVs in all life forms is increasing exponentially. In veterinary medicine, EVs are still relatively under-researched, and we have only recently begun to explore their potential.
Naraščajoči potencial raziskav zunajceličnih veziklov v veterinarski medicini
Zunajcelični vezikli (ZV) so majhne, informacijsko bogate subcelične strukture, ki so v znanstveni skupnosti pritegnile veliko pozornosti. Zaradi njihove vsesplošne prisotnosti v telesu in njihove naravne vloge kot prenašalci informacij so dragoceni pokazatelji fiziološkega in patološkega stanja celic in tkiv. V tem trenutku število študij o prisotnosti, lastnostih in vlogi ZV v vseh oblikah življenja eksponentno narašča. V veterinarski medicini so ZV še vedno razmeroma slabo proučeni in šele pred kratkim smo začeli bolj natančno raziskovati njihov potencial.
References
Amina SJ, Azam T, Dagher F, Guo B. A review on the use of extracellular vesicles for the delivery of drugs and biological therapeutics. Expert Opin Drug Deliv 2024; 21(1): 45-70. doi: 10.1080/17425247.2024.2305115
Ba-Awadh HA, Olarinre IO, Alowaimer AN, Saadeldin IM, Swelum AA. Comparison between rapid and slow cryopreservation protocols for ram semen. Slov Vet Res 2023; 60: 249-57. doi: 10.26873/SVR-1586-2022
Cerón JJ, Ortín-Bustillo A, López-Martínez MJ, et al. S-100 Proteins: basics and applications as biomarkers in animals with special focus on calgranulins (S100A8, A9, and A12). Biology (Basel) 2023; 12(6): 881. doi: 10.3390/biology12060881
Elashry MI, Speer J, De Marco I, Klymiuk MC, Wenisch S, Arnhold S. Extracellular vesicles: a novel diagnostic tool and potential therapeutic approach for equine osteoarthritis. Curr Issues Mol Biol 2024; 46(11): 13078–104. doi: 10.3390/cimb46110780
El-Husseiny HM, Mady EA, Helal MAY, Tanaka R. the pivotal role of stem cells in veterinary regenerative medicine and tissue engineering. Vet Sci 2022; 9(11): 648. doi: 10.3390/vetsci9110648
Espejo C, Ezenwa VO. Extracellular vesicles: an emerging tool for wild immunology. Discov Immunol 2024;3(1):kyae011. doi: 10.1093/discim/kyae011
Gervasi MG, Soler AJ, González-Fernández L, Alves MG, Oliveira PF, Martín-Hidalgo D. Extracellular Vesicles, the Road toward the Improvement of ART Outcomes. Animals (Basel) 2020; 10(11): 2171. doi: 10.3390/ani10112171
Hoelzer K, Bielke L, Blake DP, et al. Vaccines as alternatives to antibiotics for food producing animals. Part 2: new approaches and potential solutions. Vet Res 2018; 49(1): 70. doi: 10.1186/s13567-018-0561-7
Kim HI, Park J, Zhu Y, Wang X, Han Y, Zhang D. Recent advances in extracellular vesicles for therapeutic cargo delivery. Exp Mol Med 2024; 56(4): 836–49. doi: 10.1038/s12276-024-01201-6
Koprivec S, Majdič G. Extracellular vesicles in domestic animals: cellular communication in health and disease. Adv Exp Med Biol 2024; 1450: 39-57. doi: 10.1007/5584_2023_779
Kumar MA, Baba SK, Sadida HQ, et al. Extracellular vesicles as tools and targets in therapy for diseases. Signal Transduct Target Ther 2024; 9(1): 27. doi: 10.1038/s41392-024-01735-1
Moccia V, Sammarco A, Cavicchioli L, Castagnaro M, Bongiovanni L, Zappulli V. Extracellular Vesicles in Veterinary Medicine. Animals (Basel) 2022; 12(19): 2716. doi: 10.3390/ani12192716
Mogas T, García-Martínez T, Martínez-Rodero I. Methodological approaches in vitrification: enhancing viability of bovine oocytes and in vitro-produced embryos. Reprod Domest Anim 2024; 59 (Suppl. 3) : e14623. doi: 10.1111/rda.14623
Monari E, Troìa R, Magna L, et al. Urine neutrophil gelatinase-associated lipocalin to diagnose and characterize acute kidney injury in dogs. J Vet Intern Med 2020; 34(1): 176–85. doi: 10.1111/jvim.15645
Özmen Ö, Kaya B, Karaman K. Transcriptome analysis and bioinformatics characterization of canine hemangiosarcoma: potential therapeutic targets. Slov Vet Res 2025; 62: 41–52. doi: 10.26873/SVR-1797-2024
Palacios A, Sampedro L, Sevilla IA, et al. Mycobacterium tuberculosis extracellular vesicle-associated lipoprotein LpqH as a potential biomarker to distinguish paratuberculosis infection or vaccination from tuberculosis infection. BMC Vet Res 2019; 15(1): 188. doi: 10.1186/s12917-019-1941-6
Pedrosa AC, Andrade Torres M, Vilela Alkmin D, et al. Spermatozoa and seminal plasma small extracellular vesicles miRNAs as biomarkers of boar semen cryotolerance. Theriogenology 2021; 174: 60–72. doi: 10.1016/j.theriogenology.2021.07.022
Piibor J, Waldmann A, Prasadani M, et al. Investigation of uterine fluid extracellular vesicles' proteomic profiles provides novel diagnostic biomarkers of bovine endometritis. Biomolecules 2024; 14(6): 626. doi: 10.3390/biom14060626
Pirisinu M. The long journey of extracellular vesicles towards global scientific acclamation. Adv Pharm Bull 2023; 13(3): 489–501. doi: 10.34172/apb.2023.049
Santos P, Almeida F. Exosome-based vaccines: history, current state, and clinical trials. Front Immunol 2021; 12: 711565. doi: 10.3389/fimmu.2021.711565
Tozon N. Translation Oncology throught the One Health Perspective. Slov Vet Res 2025; 62(Suppl. 27): 9–12. doi: 10.26873/SVR-2180-2024
Ugarte F, Santapau D, Gallardo V, et al. Urinary extracellular vesicles as a source of ngal for diabetic kidney disease evaluation in children and adolescents with type 1 diabetes mellitus. Front Endocrinol (Lausanne) 2021; 12: 654269. doi: 10.3389/fendo.2021.654269
van Niel G, D'Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol 2018; 19(4): 213-28. doi: 10.1038/nrm.2017.125
Varela L, van de Lest CHA, van Weeren PR, Wauben MHM. Synovial fluid extracellular vesicles as arthritis biomarkers: the added value of lipid-profiling and integrated omics. Extracell Vesicles Circ Nucl Acids 2024 ;5(2): 276–96. doi: 10.20517/evcna.2024.14
Welsh JA, Goberdhan DCI, O'Driscoll L, et al. Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. J Extracell Vesicles 2024; 13(2): e12404. doi: 10.1002/jev2.12404
Xiong Y, Lou P, Xu C, Han B, Liu J, Gao J. Emerging role of extracellular vesicles in veterinary practice: novel opportunities and potential challenges. Front Vet Sci 2024; 11: 1335107. doi: 10.3389/fvets.2024.1335107
Yáñez-Mó M, Siljander PR, Andreu Z, et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles 2015; 4: 27066. doi: 10.3402/jev.v4.27066
Yeo RW, Lai RC, Zhang B, Tan SS, Yin Y, Teh BJ, et al. Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. Adv Drug Deliv Rev 2013; 65(3): 336–41. doi: 10.1016/j.addr.2012.07.001
Zamboni C, Zamarian V, Stefanello D, et al. Plasma small extracellular vesicles from dogs affected by cutaneous mast cell tumors deliver high levels of miR-21-5p. Front Vet Sci 2022; 9: 1083174. doi: 10.3389/fvets.2022.1083174
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