HUMAN HERPESVIRUS EPSTEIN-BARR (EBV) AND ITS PORCINE HOMOLOGS UNVEIL THE CONSERVED MECHANISM OF RECEPTOR ENDOCYTOSIS: NEW INSIGHTS INTO VIRAL IMMUNE EVASION AND ANTIVIRAL THERAPY POTENTIAL?
DOI:
https://doi.org/10.26873/SVR-2053-2024Abstract
Over the past two years, the University of Ljubljana and the Republic of Slovenia’s public agency, the Slovenian Research and Innovation Service (ARIS), have acknowledged and celebrated several exceptional accomplishments in viral receptor research. These achievements are considered among the finest by both the University of Ljubljana and ARIS. The significance of these achievements lies in the research findings, which indicate that the EBV-BILF1 receptor encoded by the Epstein-Barr virus (EBV) could become a promising new drug target for EBV. Additionally, the research suggests pigs represent a great model for further investigations (1–4).
Humani herpesvirus Epstein-Barr (EBV) in njegovi prašičji homologi razkrivajo ohranjeni mehanizem receptorske endocitoze: nov vpogled v virusno izmikanje imunskemu sistemu in potencialne protivirusne terapije?
Univerza v Ljubljani in Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije (ARIS) sta v preteklih dveh letih prepoznali in počastili več izjemnih dosežkov na področju raziskovanja virusnih receptorjev. Ti dosežki – tako na Univerzi v Ljubljani kot na ARIS-u – sodijo med najboljše. Njihov pomen izhaja iz raziskav, ki kažejo na to, da bi se lahko receptor EBV-BILF1, kodiran na virusu Epstein-Barr (EBV), uporabljal kot obetavna nova tarča za zdravljenje EBV. Poleg tega raziskava predlaga uporabo prašičev kot modela za nadaljnje preiskave (1–4).
References
1. Mavri M, Glišić S, Senćanski M, et al. Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis. Cell Mol Biol Lett 2023; 28(1): 14. doi: 10.1186/s11658-023-00427-y
2. Mavri M, Kubale V, Depledge DP, et al. Epstein-Barr virus-vncoded BILF1 orthologues from porcine lymphotropic herpesviruses dis-play common molecular functionality. Front Endocrinol 2022; 13: 13: 862940. doi: 10.3389/fendo.2022.862940
3. Tsutsumi N, Qu Q, Mavri M, et al. Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1. Immunity 2021; 54(7): 1405–16, e1–e7. doi: 10.1016/j.immuni.2021.06.001
4. Mavri M, Spiess K, Rosenkilde MM, Rutland CS, Vrecl M, Kubale V. Methods for studying endocytotic pathways of herpesvirus encoded G Protein-Coupled Receptors. Molecules 2020; 25(23): 5710. doi: 10.3390/molecules25235710
5. Chijioke O, Müller A, Feederle R, et al. Human natural killer cells pre-vent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection. Cell Rep 2013; 5(6): 1489–98. doi: 10.1016/j. celrep.2013.11.041
6. Huang CA, Fuchimoto Y, Gleit ZL, et al. Posttransplantation lymphop-roliferative disease in miniature swine after allogeneic hematopoietic cell transplantation: Similarity to human PTLD and association with a porcine gammaherpesvirus. Blood 2001; 97(5): 1467–73. doi: 10.1182/blood.v97.5.1467
7. Dor FJ, Doucette KE, Mueller NJ, et al. Posttransplant lymphoprolif-erative disease after allogeneic transplantation of the spleen in min-iature swine. Transplantation 2004; 78(2): 286–91. doi: 10.1097/01. tp.0000128342.6424
8. Chee MS, Satchwell SC, Preddie E, Weston KM, Barrell BG. Human cytomegalovirus encodes three G protein-coupled receptor homo-logues. Nature 1990; 344(6268): 774–7. doi: 10.1038/344774a0
9. Kledal TN, Rosenkilde MM, Schwartz TW. Selective recognition of the membrane-bound CX3C chemokine, fractalkine, by the human cytomegalovirus-encoded broad-spectrum receptor US28. FEBS Lett 1998; 441(2): 209–14. doi: 10.1016/s0014-5793(98)01551-8
10. Rosenkilde MM. Virus-encoded chemokine receptors--putative novel antiviral drug targets. Neuropharmacology 2005; 48(1): 1–13. doi: 10.1016/j.neuropharm.2004.09.017
11. Ehlers B, Ulrich S, Goltz M. Detection of two novel porcine herpesvi-ruses with high similarity to gammaherpesviruses. J Gen Virol 1999; 80: 971–8. doi: 10.1099/0022-1317-80-4-971
12. Müller-Durovic B, Jäger J, Engelmann C, et al. A metabolic dependency of EBV can be targeted to hinder B cell transformation. Science 2024: eadk4898. (ahed of print) doi: 10.1126/science.adk4898 (ahed of print)
13. Arfelt KN, Fares S, Rosenkilde MM. EBV, the human host, and the 7TM receptors: defense or offense? Prog Mol Biol Transl Sci 2015; 129: 395–427. doi: 10.1016/bs.pmbts.2014.10.011
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