INTERDISCIPLINARY APPROACHES FOR ONCOLOGICAL TREATMENTS: PROTON THERAPY AT THE INTERSECTION OF PHYSICS AND MEDICINE

Authors

  • Maša Čater Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, 1230 Domžale, Slovenia; masa.cater@bf.uni-lj.si

DOI:

https://doi.org/10.26873/SVR-1957-2024

Keywords:

proton, therapy, physics, cancer

Abstract

The inspiration for writing this editorial came from a recent visit to the European Organization for Nuclear Research (CERN, Conseil Européen pour la Recherche Nucléaire) in Geneva. There I had the opportunity to take a closer look at the technology of proton production and acceleration in cyclotrons. I was impressed by this direct insight into physical findings that have an impact on many other scientific fields. I learned how these scientific discoveries are used in medicine, especially in oncology, and how this interdisciplinary approach can improve patients' lives. This experience gave me a new perspective and encouraged me to research and write about this important and innovative field. In the following, we will explore how proton therapy has changed the way and success of treatments in oncology and how the interdisciplinary collaboration between physics and medicine has contributed to this progress. In addition, I have focused on the relevance of this technology to veterinary medicine and the potential it offers for improving cancer treatment in our pets.

Interdisciplinarni pristopi k onkološkim zdravljenjem: Protonska terapija na presečišču fizike in medicine

Navdih za pisanje tega uredniškega članka je nastal z nedavnim obiskom Evropske organizacije za jedrske raziskave (CERN, Conseil Européen pour la Recherche Nucléaire) v Ženevi. Tam sem imela priložnost pobliže spoznati tehnologijo pridobivanja protonov in njihovega pospeševanja v ciklotronih. Ta neposreden vpogled v fizikalno znanje, ki seva v mnoga druga znanstvena področja, me je navdušil. Spoznala sem, kako se ta znanstvena odkritja uporabljajo v medicini, zlasti v onkologiji, in kako lahko ta interdisciplinarni pristop izboljša življenja bolnikov. Ta izkušnja mi je dala novo perspektivo in me spodbudila k raziskovanju in pisanju o tem pomembnem in inovativnem področju. V nadaljevanju bomo raziskali, kako je protonska terapija preoblikovala način in uspešnost zdravljenj v onkologiji in kako je interdisciplinarno sodelovanje med fiziko in medicino prispevalo k temu napredku. Pri tem sem se osredotočila o pomenu te tehnologije za veterinarsko medicino in kakšen potencial predstavlja pri izboljšanju zdravljenja raka pri naših ljubljenčkih.

References

Bošnjak D. S protoni nad tumorje. Ljubana: Delo, 2019. https://www.delo.si/novice/znanoteh/s-protoni-nad-tumorje/ (13. 2. 2024)

CERN. Accelerators. Geneve: CERN, 2024. https://home.cern/science/accelerators (13. 2. 2024)

CERN. AWAKE. Geneve: CERN, 2024. https://home.cern/science/accelerators/awake (13. 2. 2024)

CERN. The proton synchrotron. Geneve: CERN, 2024. https://home.cern/science/accelerators/proton-synchrotron (13. 2. 2024)

Evaluation of flash proton RT in dogs with bone cancer of the leg. Lancaster: Penn Veterinary Supply, 2019. https://www.vet.upenn.edu/research/clinical-trials-vcic/all-clinical-trials/clinicaltrial/osteosarco¬ma-evaluation-of-flash-proton-rt-in-dogs-with-bone-cancer-of-the-leg (13. 2. 2024)

Ferlič Žgajnar B. Ni znano, kdaj bo Slovenija dobila protonski center. Ljubljana: Delo, 2022. https://www.delo.si/novice/slovenija/ni-znano-kdaj-bo-slovenijadobila-protonski-center/ (13. 2. 2024)

Lomax AJ. Intensity modulated proton therapy and its sensitiv¬ity to treatment uncertainties 2: the potential effects of inter-fraction and inter-field motions. Phys Med Biol 2008; 53(4): 1043–56. doi: 10.1088/0031-9155/53/4/015

Maughan R. Proton therapy: behind the scenes. Philadelphia: OncoLink, 2022. available online: https://www.oncolink.org/cancer-treatment/radiation/types-of-radiation-therapy/pr oton-therapy/overviews-of-proton-therapy/proton-therapy-behind-the-scenes (13. 2. 2024)

Pearson E, et al. Development of cyclotrons for proton and particle therapy. In: Rath AK, eds. Particle radiotherapy: emerging technology for treatment of cancer. New Delhi: Springer, 2016: 21-35.

Prešeren P. V centru za protonsko in ionsko terapijo MedAustron: novi načini zdravljenja dajejo upanje bolnikom. Ljubljana: MMC RTV SLO, 2022. https://www.rtvslo.si/znanost-in-tehnologija/v-centru-za-pro¬tonsko-in-ionsko-terapijomedaustron-novi-nacini-zdravljenja-dajejo-upanje-bolnikom/651115 (13. 2. 2024)

Rozanova OM, Smirnova EN, Belyakova TA, Strelnikova NS, Shemyakov AE, Smirnov AV. The effect of irradiation with a sequence of neutrons and protons on the tumor response of solid ehrlich carcinoma and skin reactions in mice in the early and long terms. Biophysics 2022; 67(5): 802–10. doi: 10.1134/S0006350922050153

Schippers JM. Cyclotrons for particle therapy. CERN YelloW Reports 2017; 1: 165–75. doi: 10.23730/CYRSP-2017-001

Schneider M, Bodenstein E, Bock J, et al. Combined proton radiogra¬phy and irradiation for high-precision preclinical studies in small ani¬mals. Front Oncol 2022; 12: 982417. doi: 10.3389/fonc.2022.982417

Tsuboi K. Early history of biology and clinical application of proton beam therapy. In: Tsuboi K., (eds) Proton beam radiotherapy. Singapore: Springer, 2020: 9–21.

Wikipedia. Particle accelerator. San Francisco: Wikimedia Foundation, 2024. https://en.wikipedia.org/wiki/Particle_accelerator (13. 2. 2024)

Wilson RR. Radiological use of fast protons. Radiology 1946; 47(5): 487–91. doi: 10.1148/47.5.487

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Published

2024-03-30

How to Cite

Čater, M. (2024). INTERDISCIPLINARY APPROACHES FOR ONCOLOGICAL TREATMENTS: PROTON THERAPY AT THE INTERSECTION OF PHYSICS AND MEDICINE. Slovenian Veterinary Research, 61(1), 5–8. https://doi.org/10.26873/SVR-1957-2024

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Section

Editorial