INTRATHORACIC AND EXTRATHORACIC METASTASES IN PIRLAK EWES WITH OVINE PULMONARY ADENOCARCINOMA (JAAGSIEKTE)
DOI:
https://doi.org/10.26873/SVR-1769-2023Keywords:
extrathoracic metastasis, intrathoracic metastasis, jaagsiekte sheep retrovirus, Pırlak ewe, ovine pulmonary adenocarcinomaAbstract
Ovine pulmonary adenocarcinoma (OPA) is a contagious neoplastic disease caused by jaagsiekte sheep retrovirus (JSRV) and is characterized by chronic respiratory clinical signs. In this study we describe intrathoracic and extrathoracic metastases in Pırlak ewes naturally infected with JSRV. Two Pırlak sheep flocks brought from two different provinces had progressive respiratory distress, nasal discharge, cough, and emaciation, and nine ewes from these two flocks were necropsied at the request of the owners. Gross findings revealed purple colored and consolidated cranioventral lung lobes with scattered white nodules of various sizes. One ewe had metastasis in the mediastinal lymph node, and another had metastasis in the left kidney. Histopathological examinations of the tumors in the lungs and metastases showed papillary and acinary growth patterns. Immunohistochemically, strong JSRV-Env expression was observed in neoplastic cells.
Intratorakalne in ekstratorakalne metastaze pri ovcah Pırlak z ovčjim pljučnim adenokarcinomom (jaagsiekte)
Izvleček: Pljučni adenokarcinom pri ovcah (OPA) je nalezljiva neoplastična bolezen, ki jo povzroča retrovirus ovc jaagsiekte (JSRV) in za katero so značilni kronični klinični znaki na dihalih. V tej študiji opisujemo intratorakalne in ekstratorakalne metastaze pri ovcah Pırlak, naravno okuženih z JSRV. Pri dveh čredah ovc pasme Pırlak, pripeljanih iz dveh različnih pokrajin, so se pojavili progresivna dihalna stiska, izcedek iz nosu, kašelj in izčrpanost, devet ovc iz teh dveh čred pa je bilo na zahtevo lastnikov evtanaziranih. Grobe ugotovitve so pokazale vijolično obarvane in konsolidirane kranioventralne pljučne lobe z razpršenimi belimi noduli različnih velikosti. Ena ovca je imela metastaze v mediastinalni bezgavki, druga pa v levi ledvici. Histopatološke preiskave tumorjev v pljučih in metastaz so pokazale papilarne in acinarne vzorce rasti. Imunohistokemično je bilo v neoplastičnih celicah ugotovljeno močno izražanje JSRV-Env.
Ključne besede: ekstratorakalne metastaze; intratorakalne metastaze; ovčji retrovirus jaagsiekte; ovca Pırlak; ovčji pljučni adenokarcinom
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