MELOXICAM-INDUCED GASTROPATHY IN DOGS: CLINICAL, BIOCHEMICAL, ENDOSCOPIC FEATURES AND TRIALS FOR PREVENTION

Authors

  • Gehad Ezzat Nassar Department of Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Sharkia, Egypt, Corresponding author, E-mail: gehadnassar095@gmail.com https://orcid.org/0000-0002-2833-311X
  • Yasmin Hassan Bayumi Department of Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Sharkia, Egypt
  • Hatem Mohammed Selim Department of Surgery, Anesthesiology and Radiology, Zagazig University, 44511, Zagazig, Sharkia, Egypt
  • Shimaa Ezzeldein Department of Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Sharkia, Egypt

DOI:

https://doi.org/10.26873/SVR-1571-2022

Keywords:

endoscopy, esomeprazole, gastropathy, meloxicam, misoprostol

Abstract

This study was conducted to evaluate and to compare the clinical, hemato-biochemical and endoscopic aspects of gastropathy in dogs treated with meloxicam alone or incombination with esomeprazole and misoprostol. Twenty baladi healthy dogs were included in the experimental study. Dogs were divided into four groups each group consisting of five animals; Group I (control group), the group that does not receive any medication. Meloxicam treated groups divided into: Group II which received meloxicam at a dose of 0.2 mg/kg BWT per OS /24 hr. Group III  animals received the same previous dose of meloxicam and esomeprazole at a dose of 1mg/kg BWT per OS /24 hr. Group IV  animals received the same dose of meloxicam and misoprostol 3μg /kg BWT per OS tid. Upon drug administration, dogs were kept under observation for 14 consecutive days. Clinical and hemato-biochemical  analysis were evaluated across time (T0, T3, T7, T10 and T14). The image analysis of the gastroscopic examination was evaluated across time (T0, T7 and T14), endoscopic examinations were applied to all animals in four groups at three time points (T0, T7, and T14), endoscopic lesions were scored by use of a 5-point scale. Clinically, the most common clinical sings in dogs with Meloxicam induced- gastropathy were inappetence to anorexia, hematemesis, melena, abdominal pain and weakness, the specific endoscopic lesions of gastropathy were gastric erosion, hemorrhage and ulcers. Serum gastrin concentration is a biochemically sensitive indicator of gastropathy. The overall results concluded that meloxicam-induced gastropathy was more severe in group II compared to groups III and group IV. The proton pump inhibitor (esomeprazole) was more effective and better tolerated than misoprostol. 

References

● 1. Maguilnik I, Neumann WL, Sonnenberg A, Genta RM. Reactive gastropathy is associated with inflammatory conditions throughout the gastrointestinal tract. Alimentary Pharmacology and Therapeutics. 2012; 36 (8): 736–43.

● 2. Laine L. Nonsteroidal anti-inflammatory drug gastropathy, Gastrointest Endosc Clin N Am 1996; 6 (3): 489–504.

● 3. Meddings JB, D Kirk, Olson ME. "Non-invasive detection of non-steroidal anti-Inflammatory drug-induced gastropathy in dogs." Am J Of Vet Res 1995; 56 (8): 977–81.‏

● 4. Brown SA. Renal effects of nonsteroidal anti-inflammatory drugs, in Kirk RW (ed): Current Vet Therapy X Philadelphia, PA, Saunders,1989; 1158–61.

● 5. Schmidt H. Efficacy and safety of meloxicam in the control of peri-operative pain in the dog. Proceedings of the Recent Advances in Non-Steroidal Anti-Inflammatory Therapy in Small Animals Symposium, Paris, France, June, 1999; 71–4.

● 6. Engelhardt G, Bogel R, Schnitzler CHR, Utzman R. Meloxicam: Influence on arachidonic acid metabolism. Part II. Invivo findings. Biochem Pharmacol 1996; 51, 29–38.

● 7. Van Ryn J, Pairet M. Inflammation and NSAIDs: COX-1 and COX-2 and preferential COX-2 inhibition. Proceedings of the Recent Advances in Non-Steroidal Anti-Inflammatory Therapy in Small Anim Symposium, Paris, France, June 1999; 15–21.

● 8. Bjorkman DJ. Nonsteroidal anti–inflammatory drug–induced gastrointestinal injury. Am J Med Sci 2006; 101, 25–32.

● 9. Enberg TB, Braun LD, Kuzma AB. Gastrointestinal perforation in five dogs associated with the administration of meloxicam. J Vet Emerg Crit Care 2006; 16: 34–43.

● 10. Elfadadny AR, Beder NA, Shamaa A A, Nasr MY. Endoscopy diagnosis and follow up of treatment of experimental gastric ulcer in dogs. Eur J of Pharmaceutical and Med Research, ejpmr, 2018; 5 (2), 32–8.

● 11. Elfadadny A, Mandour AS, Ragab R F, Alsharif K F, Batiha GES, Samir H, Beder, NA. A comparative time‐dependent study of hematology, serum gastrin concentrations, and gastroscopic assessment of meloxicam‐induced gastric ulceration in dogs. J of Vet Intern Med 2021; 35 (5), 2196–204.‏

● 12. Parrah JD, Moulvi BA, Gazi MA, Makhdoomi DM, Athar H, Dar S and Mir AQ. Gastric ulceration in dog: A review, Vet .World 6 (7): 449-454. doi:10.5455/vetworld.2013.449–54.

● 13. Forsyth SF, Guilford WG, Lawoko CR. Endoscopic Evaluation of The Gastro-duodenal Mucosa Following Non-Steroidal Anti-Inflammatory Drug Administration. New Zealand Vet J 1996; 44: 179–81.

● 14. Jones SM, Gaier A, Enomoto H, Ishii P, Pilla R, Price J, Tolbert MK. The effect of combined carprofen and omeprazole administration on gastrointestinal permeability and inflammation in dogs. J Of Vet Inter Med 2020; 34 (5), 1886–93.‏

● 15. Tolbert MK. Gastroprotective therapy. Vet Clin Small Anim Practice 2021; 51 (1), 33–41.‏

● 16. Johnston SA, Leib MS, Forrester SD, et al. The effect of misoprostol on aspirin-induced gastroduodenal lesions in dogs. J Vet Intern Med 1995; 9: 32–8.

● 17. Grindem CB. Schalm's Vet Hematol, 6th edition. Editors, 2011; Douglas J, Weiss K, Jane Wardrop.

● 18. Fergestad ME, Jahr TH, Krontveit RI, Skancke E. Serum concentration of gastrin, cortisoland C reactive protein in a group of Norwegian sled dogs during training and after endurance racing: a prospective cohort study. Acta Vet Scand 2016; 26; 58: 24. doi: 10.1186/s13028-016-0204-92016.‏

● 19. Narita T, Sato R, Motoishi K, Tani K, Naito Y, Hara S. The interaction between orally administered non-steroidal anti-inflammatory drugs and prednisolone in healthy dogs. J of vet Med Sci 2007; 69 (4): 353–63.‏

● 20. Forsyth SF, Guilford WG, Haslett SJ, et al. Endoscopy of the gastroduodenal mucosa after carprofen, meloxicam and ketoprofen administration in dogs. J Small Anim Pract 1998; 39: 421–4.

● 21. Davis MS, Katherine K, Williamson KK. Gastritis and gastric ulcers in working dogs. Front Vet Sci 2016; 3: 30.

● 22. Cortese MM, Tate JE, Simonsen L, Edelman L, Parashar UD. Reduction in gastroenteritis in United States children and correlation with early rotavirus vaccine uptake from national medical claims databases. Pediatr Infect Dis J 2010; 29 (6): 489–94.

● 23. Eskafian H, Tabrizi AS, Lari MA. Gastroscopic study of meloxicam, tramadol, and their combined administration on the development of gastric injuries in dogs. Topics in Companion Anim Med 2017; 32 (3), 109–13.‏

● 24. Dobre IR, Alexandru DM, Crivineanu M. Study on changes in haematological parameters following administration of nsaids in dogs. Hemoglobin (g/dl) LXV, 2019; 37–41.

● 25. Talbert A, Thuo N, Karisa J, Chesaro C, Ohuma E, Ignas J, Maitland K. Diarrhoea complicating severe acute malnutrition in Kenyan children: a prospective descriptive study of risk factors and outcome. PloS one, 2012; 7(6): e38321.

● 26. Stepan V, Sugano K, Yamada T, Park J, Dickinson C J. Gastrin biosynthesis in canine G cells. Amer.J.of Physiology-Gastrointestinal and Liver Physiol 2002; 282 (5): G766–5.

● 27. García-Sancho M, Rodríguez-Franco F, Sainz Á, Rodríguez A, Silván G, Illera JC. Serum gastrin in canine chronic lymphocytic-plasmacytic enteritis. Can Vet J 2005; 46 (7): 630.

● 28. Zhao H, Wang Y, Liu S, Yu Z, Xu Y, Lu Q, Zhao Y. Dynamic Monitoring of Cross-Bred Dogs for Translational Res. In Ulcerative Colitis, 2020.

● 29. Zou Q, Zhang X, Liu X, Li Y, Tan Q, Dan Q, Liu Z. Ficus carica polysaccharide attenuates DSS-induced ulcerative colitis in C57BL/6 mice. Food & function 2020; 11 (7), 6666–79.‏

● 30. Noviana D, Afidatunnisa K, Syafikriatillah AM, Gunanti F, Zaenab C. Diagnostic imaging and endoscopy of the schnauzer dog with upper gastrointestinal tract disorders. Indonesian J Of Vet Sci 2017; 11 (1): 1–5.

● 31. Moore LE. The advantages and disadvantages of endoscopy. J Clin Technol Small Anim Pract 2003; 18 (4): 250–3.

● 32. Lascelles B, Duncan XJ, McFarland M, Swann H. Guidelines for safe and effective use of NSAIDs in dogs." Vet Ther 2005; 6 (3): 237–51.

Downloads

Published

2023-01-26

How to Cite

Nassar, G. E., Bayumi, Y. H., Selim, H. M., & Ezzeldein, S. (2023). MELOXICAM-INDUCED GASTROPATHY IN DOGS: CLINICAL, BIOCHEMICAL, ENDOSCOPIC FEATURES AND TRIALS FOR PREVENTION. SLOVENIAN VETERINARY RESEARCH, 60(25-Suppl), 123–32. https://doi.org/10.26873/SVR-1571-2022

Issue

Section

Veterinary Medicine and The One Health Concept