• Gamal Shams Pharmacology department, Faculty of Veterinary Medicine, Zigzag University Egypt
  • Hosny Abdel Fadil Pharmacology department, Faculty of Veterinary Medicine, Zigzag University Egypt
  • Mostafa Abonorag Pharmacology department, Animal Health Research Institute, Agriculture Research Center, 41511, Ismailia
  • Fatma M. Youssef Clinical pathology department, Animal Health Research Institute, Agriculture Research Center, 41511, Ismailia, Corresponding author, E-mail: fatmayousseff@ahri.gov.eg
  • Maha M. Khalil Pharmacology department, Animal Health Research Institute, Agriculture Research Center, 41511, Ismailia
  • Nasser M. El-Sabbagh Pharmacology department, Faculty of Veterinary Medicine, Alexandria University, Egypt




Lycopene, Aflatoxin B1, hepatotoxicity, cytokine, liver apoptosis, Japanese quail


Mycotoxins are harmful auxiliary metabolites delivered by species of filamentous organisms developing on grains some time recently collect and in capacity. The study was planned to evaluate the protective role of lycopene (LYC) against Aflatoxin B1 (AFB1) induces oxidative stress, hepatic toxicity, and apoptosis in Japanese quail. Sixty Japanese quail chicks (three-week-old) were randomly allocated into four groups; Negative control group; Aflatoxin -B1 (AFB1) group (1 mg/kg feed) as positive control; lycopene supplemented group (200 mg/kg feed) and AFB1 (1 mg/kg feed) with lycopene supplemented group (200 mg/kg). The growth performance parameters, serum biochemical indices, and liver antioxidant activities as well as  histopathological studies, and  immunohistochemical pictures were performed. The results showed a significant increase on growth performance and a significant decrease on feed conversion ratio (FCR) in aflatoxin inclusion with lycopene supplemented group. Moreover, the liver enzymes (ALT, AST, and ALP) were significantly (P < 0.05) decreased.  In addition, malondialdehyde (MDA) levels significantly decreased, while superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px) and catalase (CAT) activities increased in liver tissues. Furthermore, when compared to the aflatoxin-inclusion with the lycopene supplemented group had improved liver tissue and lower levels of cytokine production (IL-6 and TNF-). In conclusion, these findings implied that dietary administration of lycopene has significantly alleviated AFB1-triggered oxidative stress, inflammatory response and liver apoptosis in Japanese quail.


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How to Cite

Shams, G., Fadil, H. A., Abonorag, M., Youssef, F. M., Khalil, M. M., & El-Sabbagh, N. M. (2023). EFFICACY OF LYCOPENE ON AFLATOXIN B1- INDUCES OXIDATIVE STRESS, HEPATOTOXICITY, APOPTOSIS AND IMMUNODEFICIENCY IN JAPANESE QUAIL. Slovenian Veterinary Research, 60(25-Suppl), 111–21. https://doi.org/10.26873/SVR-1569-2022



Veterinary Medicine and The One Health Concept