HISTOGENESIS AND MOLECULAR DEVELOPMENT OF THE LUNG IN NEW ZEALAND WHITE RABBIT (Oryctolagus cuniculus)
DOI:
https://doi.org/10.26873/SVR-1453-2021Keywords:
rabbit fetus, lung development, branching morphogenesis, alveoliAbstract
In investigating fetal organ development, fetus of the rabbit was one of the furthermost frequently handled as a model in animal investigational research. During the second half of gestation in rabbit fetuses thorax volume (TV) was the predictive factor for assessment of normal development. Concerning these fetuses, evaluation of lung development was more applicable in the 20th–29th gestational days for experiments. A large internal surface area in which the inspired air and capillary blood got in close contact to each other was specified by the lung tissue. Consequently, an efficient gas exchange was occurred. A cycle of separate but overlapping developmental processes happened to reach this target. The anlage of the left and right lungs appeared as an outpouching of the foregut endoderm during organogenesis. A repetitive process of outgrowth and branching pattern (branching morphogenesis) was occurred in each lung bud. Consequently, all of the future airways were formed mainly during the pseudoglandular stage. Repetitive airspace septation would lead to tremendous increase of the gas exchange surface area in both late fetal and postnatal lung development leading to the formation of alveoli. The first air-blood barriers were appeared and surfactant production began during the canalicular stage.
References
● 1. Karnak I, Müftüoğlu S, Cakar N, Tanyel FC.Organ growth and lung maturation in rabbit fetuses. Res Exp Med (Berl) 1999; 198: 277–87.
● 2. Karnak I, Andiran F, Tanyel FC, Müftüoğlu S, Cakar N, Büyükpamukçu N, Hiçsönmez A.The effects of nephrectomy on the developing fetus. Eur J Pediatr Surg 1996; 6: 270273.
● 3. Kizilcan F, Karnak İ, Cahit Tanyel F, Büyükpamukçu N, Hiçsönmez A.In utero defecation of the nondistressed fetus: A roentgen study in the goat. Journal of Pediatric Surgery 1994; 29: 1487-1490.
● 4. Pringle KC.Human fetal lung development and related animal models. Clin Obstet Gynecol 1986; 29: 502–13.
● 5. Ramchandi RB, Shen B, Suki B, Tepper RS. Airway branching morphology of mature and immature rabbit lungs. J Appl Physiol 2001; 90: 1584–92.
● 6. Autifi M, Ebaid A.Morphological Study of Rabbit Lung, Bronchial Tree and Pulmonary Vessels Using Corrosion Cast Technique. AL-AZHAR ASSIUT MEDICAL JOURNAL 2015; 13: 41–51.
● 7. Cardoso WV, Lu J.Regulation of early lung morphogenesis: questions, facts and controversies. Development 2006; 133: 1611–24.
● 8. McGeady TA , Quinn PJ , FitzPatrick AS, Ryan MT , Kilroy D, Lonergan P. respiratory system. In : McGeady TA. Second edition .veterinary embryology textbook. Chichester, West Sussex ; Ames, Iowa : John Wiley & Sons Inc., 2017: 232–9.
● 9. Schittny JC.Development of the lung. Cell Tissue Res 2017; 367: 427–44
● 10. Schittny J, Burri P.Development and growth of the lung. Fishman's Pulmonary Diseases and Disorders 2008: 91-114.
● 11. Woods J, Schittny J. Chapter 7:Lung structure at preterm and term birth. In Cambridge University, eds. University of Cincinnati.fetal and neonatal lung development, 2016: 126–40.
● 12. Al-Jebori JGA, Al-Jebori AKH, Al-Kafagy SM.Histogenesis of lung in local rabbit's fetuses (Oryctolagus cuniculus). Annals of Tropical Medicine & Public Health 2021;333–40.
● 13. Sadler T. Langman's medical embryology. In: Sadler T. 10thed. Williams & Wilkins, USA,2008:247–80.
● 14. Alberto M, Riveros A,Pessolato A, Santos J and MiglinoM. Development of respiratoy tract from bovine embryos. Zoological scince 2013;30:65–8.
● 15. Rutter ME . Gli2 Transcriptional Cascade During Mouse Fetal Lung Development. Phd. thesis, Institute of Medical Science, Faculty of Medicine, University of Toronto 2008.
● 16. Baba MA , Choudhary AR . Histomorphology of the Pulmonary Alveoli of Goat (Capra hircus). Veterinary World 2008;1: 312–3.
● 17. Noden DM , de Lathunta AD. The embryology of domestic animals. Williams and willins, Baltimore of London, 1985:312-–21.
● 18. Archavachotikul K, Ciccone TJ, Chinoy MR, Nielsen HC, Volpe MV.Thyroid hormone affects embryonic mouse lung branching morphogenesis and cellular differentiation. Am J Physiol Lung Cell Mol Physiol 2002; 282: 359–69.
● 19. Hassan MMH . Histomorphological studies on the lung development in fetal and newborn rabbits.Msc. AssiutUniversity, faculty of veterinary medicine. Egypt 2011.
● 20. Hines EA , Sun X . Tissue crosstalk in lung development. J. Cell. Biochem 2014;115:1469–77.
● 21. Ornitz DM , Yin Y. Signaling networks regulating development of the lower respiratory tract. Cold Spring Harb Perspect Biol 2012;4:1–19 .
● 22. Metzger RJ, Klein OD, Martin GR, Krasnow MA.The branching programme of mouse lung development. Nature 2008; 453: 745-750.
● 23. Herriges M, Morrisey EE.Lung development: orchestrating the generation and regeneration of a complex organ. Development 2014; 141: 502–13.
● 24. Knospe C. Periods and Stages of the Prenatal Development of the Domestic Cat. Anat. Histol. Embryol 2002; 31:37–51.
● 25. Schittny JC, Burri P H . Development and Growth of the Lung. Development 2007;139: 111–24.
● 26. Warburton D, El-Hashash A, Carraro G, Tiozzo C, Sala F, Rogers O, Langhe SD, Kemp PJ, Riccardi D, Torday J, Bellusci S, Shi W, Lubkin SR, Jesudason E.Lung Organogenesis. Curr Top Dev Biol 2010; 90: 73–158.
● 27. Elhafez EAA, Mohamed GK, Hussein MM.Development of the respiratory acinus in the rabbit lung. Recent Researches in Medicine and Medical Chemistry 2018; 88–94.
● 28. Peter HB.Structural Aspects of Postnatal Lung Development – Alveolar Formation and Growth. Biol Neonate 2006;89:313–22.
● 29. Berg T. C/EBP transcription factors in lung cellular differentiation and development. Institutionen för medicin/Department of Medicine 2005;1-49.
● 30. Sohi BS , Singh O. Histomorphological and histochemical studies on the lungs of buffalo during prenatal development. Indian journal of animal sciences 2006;76:219–22.
● 31. Morrisey EE, Hogan BL.Preparing for the first breath: genetic and cellular mechanisms in lung development. Dev Cell 2010; 18: 8–23.
● 32. Chen F, Desai TJ, Qian J, Niederreither K, Lu J, Cardoso WV.Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development 2007; 134: 2969–79
● 33. Goss AM, Tian Y, Tsukiyama T, Cohen ED, Zhou D, Lu MM, Yamaguchi TP, Morrisey EE.Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell 2009; 17: 290–8.
● 34. Harris-Johnson KS, Domyan ET, Vezina CM, Sun X.beta-Catenin promotes respiratory progenitor identity in mouse foregut. Proc Natl Acad Sci U S A 2009; 106: 287–92
● 35. Li Y, Gordon J, Manley NR, Litingtung Y, Chiang C.Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis. Dev Biol 2008a; 322: 145–55.
● 36. Que J, Choi M, Ziel JW, Klingensmith J, Hogan BL.Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps. Differentiation 2006; 74: 422–37.
● 37. Que J, Luo X, Schwartz RJ , Hogan BL . Multiple roles for Sox2 in the developing and adult mouse trachea. Development 2009;136: 1899–907.
● 38. Shannon JM, Hyatt BA.Epithelial-mesenchymal interactions in the developing lung. Annu Rev Physiol 2004; 66: 625–45.
● 39. Tompkins DH, Besnard V, Lange AW, Keiser AR, Wert SE, Bruno MD, Whitsett JA.Sox2 activates cell proliferation and differentiation in the respiratory epithelium. Am J Respir Cell Mol Biol 2011; 45: 101–10.
● 40. Kim IM, Ramakrishna S, Gusarova GA, Yoder HM, Costa RH, Kalinichenko VV. The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature. J Biol Chem 2005;280:78–86.
● 41. Kalin TV, Wang IC, Meliton L, Zhang Y, Wert SE, Ren X, et al. Forkhead Box m1 transcription factor is required for perinatal lung function. Proc Natl Acad Sci U S A 2008;105: 330–5.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Esraa M. Abdelbadea *, Saeed M.S. Ammar, Khaled Z. Soliman, Mervat M.H. Konsowa *
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
