ALLEVIATION HARMFUL EFFECTS OF NON- ALCOHOLIC FATTY LIVER DISEASE WITH PHYLLANTHUS NIRURI EXTRACT IN ALBINO RATS
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a serious global health problem that is strongly linked to insulin resistance, obesity, and oxidative stress. The goal of current work was to inspect the hepatoprotective and hypolipidemic effects of Phyllanthus niruri ethanolic extract (PNEE) on high fat hyperlipidemic diet –induced rat's fatty liver. A unique high-fat diet (HFD) composed of coconut oil (7.3%), beef tallow (7.3%), safflower oil (0.4%) and cholesterol (1.5%) were used in the present study for induction of NAFLD or hyperlipidemia in male Albino rats. Forty-eight clinically healthy male Albino rats were equally divided into four groups: the first served as control. The second group, rats administered ethanol extract of Phyllanthus niruri (PN) (250 mg/kg b.wt.); while the third group was rats fed diet supplemented high fat concentrated (HFCD); and the fourth was rats received combination of HFCD and PN (HFCD+PN). All treatments were given daily by oral route for 105days. All treatments were given daily by oral route for 105 days. Treatment of hyperlipidemic rats by PNEE resulted in reduction of serum liver enzymes, and improvement in proteins and lipids profile, as well as pancreatic function tests, in comparison with hyperlipidemic rats (gp.3) which showed severe biochemical alterations. This was confirmed by histopathological findings in the liver. It could be concluded that PNEE treatment has a strong hepatoprotective impact against fatty alterations in animal models, suggesting that PNEE could be used as a promising agent to prevent fatty liver disease.
Key words: Nonalcoholic fatty liver; liver enzymes; insulin; glucose; HOMA-β.